- Home
- Parkinson's...
Parkinson's Link to Gut Bacteria Suggests Unexpected, Simple Treatment
Researchers have suspected forsome time that the link between our gut and brain plays a role in the development of Parkinson's disease.
A new study just identified gut microbes likely to be involved and linked them with decreased riboflavin ( vitamin B2) and biotin (vitamin B7), pointing the way to an unexpectedly simple treatment that may help: B vitamins.
"Supplementation of riboflavin and/or biotin is likely to be beneficial in a subset of Parkinson's disease patients, in which gut dysbiosis plays pivotal roles," Nagoya University medical researcher Hiroshi Nishiwaki and colleagues write in their paper.
The neurodegenerative disease impacts almost 10 million people globally, who at best can hope for therapies that slow and alleviate symptoms. These typically begin with constipation and sleep problems, up to 20 years before progressing into dementia and the debilitating loss of muscle control.
Previous research found people with Parkinson's disease also experience changes in their microbiome long before other signs appear. So analyzing fecal samples from 94 patients with Parkinson's disease and 73 relatively healthy controls in Japan, Nishiwaki and team compared their results with data from China, Taiwan, Germany, and the US.
While different groups of bacteria were involved in the different countries examined, they all influenced pathways that synthesize B vitamins in the body. The researchers found the changes in gut bacteria communities were associated with a decrease in riboflavin and biotin in people with Parkinson's disease.
Nishiwaki and colleagues then showed the lack of B vitamins was linked to a decrease in molecules that help create a healthy mucus layer in the intestines. They suspect the weakened protective layer exposes the intestinal nervous system to more of the toxins we now encounter more regularly. These include cleaning chemicals,pesticides, and herbicides.
Such toxins lead to increased nervous system inflammation and the overproduction of α-synuclein fibrils – molecules known to amass in dopamine-producing cells in the substantia nigra part of our brains, eventually leading to the more debilitating motor and dementia symptoms of Parkinson's.
A 2003 study found high doses of riboflavin can assist in recovering some motor functions in patients who also eliminated red meat from their diets. So it's possible that high doses of vitamin B may prevent some of the damage, Nishiwaki and team propose.
This all suggests ensuring patients have healthy gut microbiomes may also prove protective, as would reducing the toxic pollutants in our environment.
Of course, with such a complicated chain of events involved in Parkinson's disease, not all patients likely experience the same causes, so each individual would need to be assessed.
"We could perform gut microbiota analysis on patients or conduct fecal metabolite analysis," explains Nishiwak.
"Using these findings, we could identify individuals with specific deficiencies and administer oral riboflavin and biotin supplements to those with decreased levels, potentially creating an effective treatment."
This research was published in npj Parkinson's Disease.
- https://www.msn.com/en-au/health/other/parkinson-s-link-to-gut-bacteria-suggests-unexpected-simple-treatment/ar-BB1oTWJ5?ocid=00000000
Related
The 3-minute yoga routine that can lower your blood sugar and stress levels
A little can do a lot.
HealthDietary Supplement Found to Reduce Aggression by Up to 28%
Keep calm and try omega-3. The fatty acids, available as dietary supplements via fish oil capsules and thought to help with mental and physical well-being, could also cut down on aggression, according to a new study. These findings haven't come out of nowhere: omega-3 has previously been linked to preventing schizophrenia, while aggression and antisocial behavior are thought in part to stem from a lack of nutrition. What we eat can influence our...
HealthPrincess Anne is out of hospital and recuperating at home after suffering head injury
Princess Anne, the sister of King Charles III, returned to her Gatcombe Park home on Friday morning, after a short stay in hospital where she was treated for minor injuries and a concussion, according to a royal source. The Princess Royal, 73, had been injured while walking near horses at the royal estate, in Gloucestershire, western England, on Sunday evening. Anne will continue to rest and recover at home, returning to public engagements when...
HealthHow to Taste Whisky Like a Pro
Despite what you might think, tasting whisky is a lot more than simply taking a big gulp, swallowing it, and exclaiming to your mates that it, “sure is smooth”. While that’s all well and good, if you want to learn how to “taste” whisky, you need to do a little more than that. Also, you […]
HealthI ate like a Victorian for a week in the name of science
It's said the mid-Victorian diet was among the healthiest of all time.
Health‘No safe level’: Politicians ‘spineless’ over pill testing trials in Victoria
Sky News host Chris Kenny says politicians are “too spineless” to say there is no safe level of drugs as pill testing in festivals is set to be trialled in Victoria.
HealthMichael J Fox flashes peace sign from wheelchair amid devastating Parkinson's battle
He enjoyed a night in London.
HealthA Signal of Future Alzheimer's May Be Hidden in The Way You Speak
We're still not sure exactly what causes Alzheimer's disease, but we know what its effects look like, and we're getting better at detecting the early signs of it – including, perhaps, those in our speech. Scientists from Boston University have developed a new AI ( artificial intelligence) algorithm that analyzes the speech patterns of those with mild cognitive impairment (MCI). It can predict a progression from MCI to Alzheimer's within six...
Health